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Lupus is a chronic disease with a variety of symptoms caused by inflammation in one or more parts of the body.  It is estimated that it
affects over 1:1000 Canadians.

Lupus belongs in the family of diseases that includes rheumatoid arthritis, multiple sclerosis, juvenile diabetes, and scleroderma.

The most common type of lupus is SLE (systemic lupus erythematosus).  It is a complex and baffling condition that can target any tissue or organ of the body, including skin, muscles, joints, blood and blood vessels, lungs, heart, kidneys and the brain.

There are other types of lupus which mainly affect the skin.  A few individuals develop drug-induced lupus as a response to some medications used to treat other conditions.  These symptoms disappear when the person stops taking the medication. 

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Anyone can:  women, men, children.  Between the ages of 15-45, eight times more women than men get lupus.  In those under 15 and over 45, both sexes are affected equally. 


No one knows for sure.  What we do know is that, in lupus, the immune system (the body's defense against viruses and bacteria) is unable to tell the difference between intruders and the body's own tissues.  Trying to do its job, it attacks parts of the body, causing inflammation and creating the symptoms of lupus.

Because it occurs most often in women of childbearing age, it seems
evident that there is a link between lupus and some hormones, but how this works remains uncertain.  It also appears that inherited factors may make some people more likely to develop lupus, but these also are not clear yet.

Until science fully understands how the immune system works, the specific cause of lupus remains unknown.


General statements about symptoms of lupus can be helpful, but each person's experience will be very different.

Some people will have only a few of the many possible symptoms. Because it can target any of the body's tissues, lupus is often hard to pin down or diagnose. That's why it is called "the disease with 1000 faces".

Before symptoms specific to lupus occur, flu-like symptoms may appear, along with severe fatigue, a sudden unexplained loss or gain in weight, headaches, hair loss, hives, high blood pressure, or changes in the colour
of fingers in the cold.

Any of the following may indicate to a doctor that lupus is present. A
person with lupus may experience:

  1. Joint pain, sometimes with swelling, redness and heat

  2. A red rash across upper cheeks and bridge of the nose

  3. Extreme fatigue

  4. An unusual reaction to sunlight

  5. A red scaly rash

  6. Small, usually painless sores inside the nose or mouth

  7. Chest pain, worse when lying down or inhaling

  8. Swelling of feet and legs, weight gain

  9. Seizures or severe psychological symptoms

  10. Abnormalities in blood chemistry which show up in blood tests

This is far from a complete list of symptoms, and the diagnosis of lupus must be made by a doctor.


While there is no cure yet, with treatment most people with lupus can look forward to a normal life expectancy.  The treatment plan will depend in part on the type and severity of symptoms.

There are many medications that can control symptoms, from a mild anti-inflammatory to some very potent steroids.  Generally, a doctor will prescribe the least powerful one, over the shortest time, that can do the job.  Medications may have side effects, and, in combination, some drugs can interact to produce unexpected reactions.  Both doctor and patient need to be aware of these possibilities, and watch for them.


Many doctors and scientists are investigating the cause and cure of lupus.  At medical centres worldwide (including Canada), research has led to improved tests and techniques for diagnosis and better methods for predicting flares.  These allow doctors to start treatment sooner, which improves chances for success.

As part of research, many centres collect and store patient information and statistics.  The results of this data can help doctors and patients make better decisions about treatment of an increasingly wide range of symptoms.  This, along with today's advances in technology, the greater awareness about lupus, and the promise of a cure, gives hope to all whose lives are touched by lupus. 

More Information

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